Active Constituents and Proposed Mechanism of Action
Fenugreek seeds contain alkaloids (mainly trigonelline) and protein high in lysine and L-tryptophan. Its steroidal saponins (diosgenin, yamogenin, tigogenin, and neotigogenin) and mucilaginous fibre are thought to account for many of the beneficial effects of fenugreek. The steroidal saponins are thought to inhibit cholesterol absorption and synthesis,2 while the fibre may help lower blood sugar levels.3 One human study found that fenugreek can help lower cholesterol and blood sugar levels in people with moderate atherosclerosis and non-insulin-dependent (type 2) diabetes.4 Preliminary and double-blind trials have found that fenugreek helps improve blood sugar control in patients with insulin-dependent (type 1) and non-insulin-dependent (type 2) diabetes.5, 6, 7 Double-blind trials have shown that fenugreek lowers elevated cholesterol and triglyceride levels in the blood,8, 9 This has also been found in a controlled clinical trial with diabetic patients with elevated cholesterol.10 Generally, fenugreek does not lower HDL (“good”) cholesterol levels.
Due to the somewhat bitter taste of fenugreek seeds, de-bitterized seeds or encapsulated products are preferred. The German Commission E monograph recommends a daily intake of 6 grams.11 The typical range of intake for diabetes or cholesterol-lowering is 5–30 grams with each meal or 15–90 grams all at once with one meal. As a tincture, 3–4 ml of fenugreek can be taken up to TID.
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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2021.