Intestinal Permeability: Leaky Gut Syndrome

Number 12. For Professional Use Only

The gastrointestinal tract is a complex organ system combining endocrine, nervous, immune and digestive functions. The mucosal surface area of the gastrointestinal tract (>200 square metres), more than 150 times the surface area of the skin, can be viewed as the body’s largest immune organ system; the absorption of nutrients or exclusion of toxic substances depends upon the proper functioning of intestinal mucosal cells. In addition to performing the vital functions of absorbing and digesting nutrients, the small intestine also plays a key role in maintaining an integral and effective barrier, preventing the entrance of toxic species and molecules into general systemic circulation.

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