Technical Review - Magnesium
Magnesium is the second most abundant intracellular cation yet deficiency is remarkably common and may result in a wide range of clinical symptoms and disorders that are, at least in part, due to alterations to magnesium dependent enzyme systems. Magnesium plays a critical role in over 600 bodily reactions, including a large number of vital cellular processes including oxidative phosphorylation, glycolysis, DNA transcription and protein synthesis. Not surprisingly, magnesium deficiency has been associated with widespread illnesses including cardiovascular disease, hypertension, diabetes, migraine headaches, cognitive and behavioural disorders, depression, anxiety, premenstrual syndrome, muscle cramps, muscle weakness and chronic fatigue. Fortunately magnesium supplementation is relatively inexpensive, very safe and a highly effective way to improve many symptoms of magnesium deficiency2.
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