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Study Shows Importance of Folic Acid Timing For Pregnancy

Study Shows Importance of Folic Acid Timing For Pregnancy

New research carried out in 240,954 pregnant women has found that taking folic acid supplements post conception may be too late to have a positive effect on key markers of a healthy pregnancy.

This latest research on the hot topic of folic acid supplementation and pregnancy was carried out by researchers from the UK, America and China using data from the Jiaxing Birth Cohort.

The impact of maternal folate status on infant neural tube defects and other congenital disorders is now well accepted.  However the association between folic acid supplementation and other outcomes like birth weight and preterm birth is still unclear.

Results of this latest study showed that supplementation with folic acid pre-conception was associated with 8% lower risk of preterm birth and 19% lower risk of small-for-gestational-age birth compared with those with didn’t supplement with the nutrient.  However, when folic acid supplementation was started post conception no association was found with either outcome.

The study also found that women were more likely to start supplementation post-conception (14%) than pre-conception (10%).

The message is now loud and clear - folic acid supplementation is important in pregnancy, particularly during the pre-conception period and continuing throughout pregnancy.  Our advice is to start taking a high quality pregnancy supplement that contains optimal levels of folic acid from the moment you start thinking about having a baby.  That way you can ensure folate status builds up to  an optimal level at the point of conception, which appears to be the critical time.  Women would normally need 200mcg folic acid daily, yet this increases to 600mcg per day when pregnant – the equivalent of eating well over a kilo of broccoli daily – taking a supplement is therefore a simple and effective way to ensure this higher intake. 

References

Zheng JS, Guan Y et al. Pre-conceptional intake of folic acid supplements is inversely associated with risk of preterm birth and small-for-gestational-age birth: a prospective cohort study.  British Journal of Nutrition. Published online ahead of print, doi: 10.1017/S0007114515004663