OptiResol 60 Capsules
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OptiResol 60 Capsules

Fish oil enriched with specialised pro-resolving mediators (SPMs) to support the optimal resolution of inflammation

80 % of 100
  • Gluten-free
  • Dairy-free
  • Soya-free
  • Non-GMO
  1. The Impact of Specialised Pro-Resolving Mediators on Inflammation

    The Impact of Specialised Pro-Resolving Mediators on Inflammation

    Learn more about the incredible chemical mediators called specialised pro-resolving mediators (SPMs) that are produced naturally in the body and are essential for keeping pain and inflammation in check.
  2. Why SPMs Are An Important Consideration For Long COVID

    Why SPMs Are An Important Consideration For Long COVID

    Only recently have scientists discovered incredible compounds SPMs, which act as inflammation's 'stop signals'. Find out more about what SPMs are and why they may hold significant promise for Long COVID.
  3. What’s In Your Post-Viral Fatigue Toolkit?

    What’s In Your Post-Viral Fatigue Toolkit?

    Since the emergence of SARS-CoV-2, and with awareness in post-viral fatigue at an all time high, we take a closer look at what therapeutic possibilities we have in our toolkits for this complex health problem.
  • Fish oil enriched with specialised pro-resolving mediators, also known as SPMs.
  • SPMs are metabolites of omega-3 fatty acids EPA and DHA.
  • These key metabolites are 17-HDHA, 18-HEPE and 14-HDHA.
  • SPMs are produced by the body but diet, lifestyle or poor health can affect natural production of these metabolites.
  • SPMs support the resolution of inflammation, and may be particularly helpful for long-term, chronic inflammation.


Each capsule typically contains:


% NRV*

Fish oil



Omega-3 fatty acids



    EPA (Eicosapentaenoic acid)



    DHA (Docosahexaenoic acid)



    17-HDHA (17-hydroxy-docosahexaenoic acid)



    18-HEPE (18-hydroxy-eicosapentaenoic acid)



    14-HDHA (14-hydroxy-docosahexaenoic acid)




* NRV is the Nutrient Reference Value
✝ NRV not yet established

Encapsulated with:
Gelatin (bovine derived from cows)
Tocopherol-rich extracts

OptiResol is a fish oil enriched with substances known as SPMs - "specialised pro-resolving mediators". Sometimes described as "next generation fish oil", SPMs are metabolites of omega-3 fatty acids which may help to promote the optimal resolution of inflammation, following injury or trauma or in those with long-term, chronic inflammation, and promote a return to homeostasis ("steady state" or normal function).

‘Specialised Pro-resolving Mediators’ (SPMs) are metabolites derived from the omega-3 fatty acids EPA and DHA. Key SPMs include 17-HDHA, 18-HEPE and 14-HDHA. Whilst these can be produced naturally in the body, production can be impaired by diet, lifestyle choices, illness or age, and these metabolites have recently been identified as key components in the resolution of inflammation, following injury or crisis. Whilst acute inflammation is a normal defense mechanism, if left unresolved, it can lead to long-term, chronic inflammation. This may be linked to low levels of SPMs in the body, because SPMs are thought to play a critical role in returning the body to homeostasis following injury, infection or physical challenge.

Resolution is part of the healing process, the natural way in which our immune systems end the inflammatory response following injury or physical challenge. Resolution differs from the actions of anti-inflammatory agents, which inhibit the natural inflammatory process.

Although our body can use omega-3 fatty acids like EPA and DHA to generate SPMs, there are many enzymatic steps involved in this process. The impact of ageing, poor diet and general health status can inhibit the body's production of SPMs from these fatty acids. Supplementing with SPMs directly provides a more targeted and direct support for the body's affected tissues to return to health.

Orders placed by 2pm Monday - Friday will be despatched the same working day.


Delivery Costs

Royal Mail 24: Free Delivery

Royal Mail Tracked 24: £5.50 for orders under £45. Free for orders over £45. 

Special Delivery Before 1pm: £9.50


NB Please note that Royal Mail 24 is not available for orders over £100. Royal Mail Tracked 24 is offered as an alternative option.

Suitable for those looking for support for inflammation, particularly long-term, chronic or infectious inflammation.

If pregnant, breastfeeding, taking medication or have a medical condition, consult a healthcare practitioner before taking this product. If taking anti-coagulants, consult a medical doctor before taking this product.

Contains ingredients derived from:

1 capsule, or up to 3 daily.

Nutri Advanced supplements should not be used as a substitute for a varied diet and healthy lifestyle. Results may vary between individuals.